Wiki source code of Amadee-20-Microbiome

Version 14.1 by Barry Bishop on 2020/02/14 17:44

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1.1	1	=== Details ===
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	3	\|Acronym\|Microbiome
	4	\|Description\|Focussing on the (analog) astronauts' microbiome as a health factor
	5	\|Principal Investigator (PI)\|Dr. Bärbel Fösel
	6	\|Organisation \|Helmholtz Center Munich - Research Unit Comparative Microbiome Analysis
	7	\|Co-Investigators\|Susanne Kublik BSc, Prof. Dr. Michael Schloter
	8
	9	=== Summary ===
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	11	(% class="image" style="float:right" %)
	12	(((
11.1	13	[[image:logo_microbiome.png]]
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	16	The Microbiome experiment focusses on the (analog) astronauts' microbiome as a health factor. To date studies on the effects of spaceflight on astronauts' microbiomes are rare. In the experiment, the impact of short-term missions on the microbiome will be
	17	assessed by characterizing the analog astronauts' skin and gut microbiome before, during and after the mission. The collected data is to be correlated with metadata on the analog astronauts' health and hygiene as well as environmental factors.
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	19	The research questions to be investigated are:
	20
	21	1. Is there an observable effect already on the short term and - if so - is it rather on structural or functional level?
	22	1. How resilient is the microbiome towards short-term stress? - How fast and to which extent does it react and how fast and to which extent does it turn back to the initial state?
	23	1. Are there key stone species that can be used as markers for specific states or that even function as triggers?
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12.1	26	(((
	27	[[image:MICROBIOME.png]]
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	30	(c) Jonathan Bailey, National Human Genome Research Institute, NIH
	31	)))
	32	)))
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1.1	34	Samples of the microbiome will be taken every couple of days during the mission, as well as before and after mission for reference. The skin microbiome will be sampled with swabs of the elbow crease and fecal samples are to be taken as proxies for the gut microbiome. For correlation of microbiome data with information on the astronauts’ habits and health status metadata will be collected by means of a questionnaire.