Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-Genes4Mars
	1	+Amadee-24-SAMPLE

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1	1	=== Details ===
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3		-|**Acronym**|Genes4Mars
4		-|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
5		-|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
6		-|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
	3	+|**Acronym**|SAMPLE
	4	+|**Description**|Rover traversability, teleoperations for sample acquisition and transport to Hab using semi-autonomous traverse finding rover.
	5	+|**Principal Investigator (PI)**|Gerald Steinbauer-Wagne ~| [[steinbauer@ist.tugraz.at>>mailto:steinbauer@ist.tugraz.at]]
	6	+|**Organisation** |Research Group for Autonomous Intelligent Systems, Institute of Software Technology, Graz University of Technology
7	7	|**Co-Investigators**|(((
8		-Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
	8	+Matthias Eder (Robot Software Specialist)
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	10	+Hamid Didari (Robot Software Specialist)
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	12	+Richard Halatschek (Robot Engineer)
9	9	)))
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11	11	=== Summary ===
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15	15	[[image:ACT_manifest.png||height="266" width="399"]]
16	16	)))
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18		-Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during space exploration missions, e.g. to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew. Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
	22	+Rover systems used in planetary exploration, for example Curiosity and Perseverance, have already proven successful in past missions. However, the time delay between the Martian exploration site and the Mission Support Center (MSC) on earth as well as safety issues constitute limiting factors in the autonomy of a rover. Semi-Autonomous Robot Assistance for Planetary Exploration (SAMPLE) addresses this issue.
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20		-The main objective of Genes4Mars is a retrospective investigation of changes in risk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG) analysis can be used to monitor astronaut performance during planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiac function-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
	24	+Based on the MERCATOR experiment in AMADEE-20, SAMPLE aims to extend the aera of use and autonomy of rovers. SAMPLE investigates robot capabilities such as photogrammetry, in-situ instrument placing, and sample collection combined with improved semi-autonomous robot control and the integration into the exploration cascade for supporting geological hypotheses.
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	26	+The expected outcome of the SAMPLE project is to provide data products like 3D maps, images, or special measurements shortly after the exploration task of a robot. Moreover, SAMPLE aims to provide sophisticated visualization and tools for better integration of the scientific capabilities of the rover into the daily exploration routine of the remote science support and the analog astronauts.
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	28	+To meet the experiment objectives, in-situ measurements and data collection will be improved by implementing a robotic arm. The level of autonomy can be adjusted by the analog astronaut. Implementing machine learning algorithms allows for improving the long-range navigation skills of the rover. To provide detailed insights on remote locations of interest to the analog astronauts and the remote science team, SAMPLE applies methods from photogrammetry and mapping.
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24	24	=== Experiment Data ===
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