Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-Genes4Mars
	1	+Amadee-24-SAMPLE

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1	1	=== Details ===
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3		-|**Acronym**|Genes4Mars
4		-|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
5		-|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
6		-|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
7		-|**Co-Investigators**|(((
8		-Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
9		-)))
	3	+|**Acronym**|SAMPLE
	4	+|**Description**|Rover traversability, teleoperations for sample acquisition and transport to Hab using semi-autonomous traverse finding rover.
	5	+|**Principal Investigator (PI)**|Gerald Steinbauer-Wagne ~|  steinbauer@ist.tugraz.at
	6	+|**Organisation** |Lunar Zebro team, Delft University of Technology
	7	+|**Co-Investigators**|Lucie Ráčková ~| [[lucie.rackova@recetox.muni.cz>>mailto:lucie.rackova@recetox.muni.cz]]
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11	11	=== Summary ===
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15	15	[[image:ACT_manifest.png||height="266" width="399"]]
16	16	)))
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18		-Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during space exploration missions, e.g. to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew. Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
	16	+The use of remote-controlled robots may increase the safety, effectiveness, and efficiency of Martian exploration. Complex control is frustrating and distractive for the operator and negatively affectsefficiency and outcome of a task. To ensure the first mentioned attributes, HUMANISE (Human Machine Interaction, Stress, and Performance) addresses design, user experience and usability of rover controllers.
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20		-The main objective of Genes4Mars is a retrospective investigation of changes in risk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG) analysis can be used to monitor astronaut performance during planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiac function-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
	18	+The expected goal of HUMANISE is to gather information about the usability of rover controllers which contribute to the future design of such controllers. Usability shall be maximized so that the operator can primarily focus on the task and is not distracted by complicated interaction with the device or occurring errors. Findings of the experiment will be used to tailor future technology development which better suit the operators needs and thus promote efficiency and effectiveness.
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	20	+Three different rover controllers will be tested by at least four analog astronauts in proximity to the rover. In the experiment, the analog astronaut is expected to perform different tasks. Consistency in the task and in the setting ensure objective comparability of the controllers in terms of its usability. Qualitive as well as quantities methods will be applied during AMADEE-24 mission. Standard questionnaires and biometrics will be applied for quantitative analysis. Interviews and video recordings will be interpreted for qualitative analysis.
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24	24	=== Experiment Data ===