Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-Genes4Mars
	1	+Amadee-24-MEROP

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1	1	=== Details ===
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3		-|**Acronym**|Genes4Mars
4		-|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
5		-|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
6		-|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
	3	+|**Acronym**|MEROP
	4	+|**Description**|Human-robotic multimodal teleoperation interface for AA teleoperations and MSC t/m visualization; this shall allow AA's to switch between semi-autonomous teleoperation and direct control.
	5	+|**Principal Investigator (PI)**|Rute Luz ~| [[rute.luz@tecnico.ulisboa.pt>>mailto:rute.luz@tecnico.ulisboa.pt]]
	6	+|**Organisation** |Institute for Systems and Robotics, Instituto Superior Técnico, University of Lisbon
7	7	|**Co-Investigators**|(((
8		-Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
	8	+Jéssica Corujeira | [[jessica.corujeira@tecnico.ulisboa.pt>>mailto:jessica.corujeira@tecnico.ulisboa.pt]]
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	10	+Rodrigo Ventura | [[rodrigo.ventura@isr.tecnico.ulisboa.pt>>mailto:rodrigo.ventura@isr.tecnico.ulisboa.pt]]
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	12	+José Luís Silva | [[jlcsa@iscte-iul.pt>>mailto:jlcsa@iscte-iul.pt]]
9	9	)))
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11	11	=== Summary ===
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15	15	[[image:ACT_manifest.png||height="266" width="399"]]
16	16	)))
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18		-Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during spaceexplorationmissions, e.g.to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew.Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
	22	+Effective interaction between the analog astronaut and a remote rover is essential to take out full advantage of the supporting asset and to ensure a successful exploration during a mission. A rover is teleoperated via the Operator Control Unit (OCU). The physical distance from the operator and the robotic vehicle leads to poor situation awareness and may cause inadequate decision-making. The OCU must be designed wisely to ensure proper human-robot interaction.
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20		-The main objective of Genes4Mars is a retrospective investigation of changes inrisk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG)analysis can be used to monitor astronaut performanceduring planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiacfunction-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
	24	+MEROP improvesthe teleoperation of rovers by providing a problem-solving toolbox to the OCU. It addresses two major issues: situation awareness and communication. Unexpected, autonomous action of the robot may cause operator insecurity and influences situation awareness in a negative way. The second challenge deals with communication and communication reliability between the operator and the robot. Issues concerning bandwidth or loss of communication impose constant risks, which need to be mitigated.
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	26	+The expected outcome of the MEROP experiment is an improved teleoperation of robotic vehicles and the implementation of an effective visualization tool that support the flight planning team in the decision-making process.
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	28	+To achieve experiment objectives, the MEROP team will implement a teleoperation interface, where the analog astronaut can choose between two interaction levels: Semi-autonomous teleoperation and direct teleoperation. Semi-autonomous teleoperation features indirect control of the robot using a virtual avatar and interface augmentation techniques. Direct teleoperation allows for the direct control of the robot to enhance situation awareness.
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26	26	=== Experiment Data ===