Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-Genes4Mars
	1	+Amadee-24-Hort3Space

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1	1	=== Details ===
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3		-|**Acronym**|Genes4Mars
4		-|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
5		-|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
6		-|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
	3	+|**Acronym**|Hort3Space
	4	+|**Description**|An automated multilevel cultivation prototype, equipped with cultivation specific full spectrum LED lights placed inside a sterile grow room in an inflatable self-erecting tent to evaluate cultivation performances, supporting the diet of the crew
	5	+|**Principal Investigator (PI)**|Luca Nardi ~| [[luca.nardi@enea.it>>mailto:luca.nardi@enea.it]]
	6	+|**Organisation** |ENEA-Biotechnology Laboratory, Casaccia Research Center
7	7	|**Co-Investigators**|(((
8		-Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
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9	9	)))
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11	11	=== Summary ===
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15	15	[[image:ACT_manifest.png||height="266" width="399"]]
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18		-Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during spaceexplorationmissions, e.g.to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew.Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
	18	+Future long-term space missions and human habitation on other planets such as Mars require a controlled ecological life-support system. Its purpose is to basically re-create a proper atmosphere, purify water and possibly sow seeds for astronauts to eat. These processes are ensured by photosynthetic algae and higher plants in a so-called “biological life support system” (BLSS).
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20		-The main objective of Genes4Mars is a retrospective investigation of changes inrisk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG)analysis can be used to monitor astronaut performanceduring planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiacfunction-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
	20	+Since the AMADEE-24 mission site mimics the harsh space environment, it is the perfect location to test such systems. Here, productive plant species shall be grown considering factors such as the absence of soil, shortage of water, limited space available.The experiment Hort3Space is therefore focusing on “microgreens” -leafy vegetables harvested as seedlings, highly acceptable by consumers as “Ready-To-Eat” (RTE) food. They are highly nutritious, hence an excellent source of vitamins and antioxidants.
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	22	+The aim of this experiment is to develop and test innovative and autonomous cultivation systems that can grow fresh food with the minimum human intervention. This way, supply transportation for long-term missions can be reduced.
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	24	+To realize this experiment, a sterile grow room in an inflatable self-erecting tent will be used to evaluate cultivation performances in extreme environments, simulating a planetary biological life support system (BLSS). It will be able to support the dietof the crew members of the analogue mission with fresh and highly nutritious, ready-to-eat vegetables. Additionally, the use of automated processes shall reduce analogue astronaut’s time required for cultivation task.
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26	26	=== Experiment Data ===