Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-Genes4Mars
	1	+Amadee-24-Staying Alive

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1	1	=== Details ===
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3		-|**Acronym**|Genes4Mars
4		-|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
5		-|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
6		-|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
7		-|**Co-Investigators**|(((
8		-Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
9		-)))
	3	+|**Acronym**|Staying Alive -Life support tasks under autonomous operationand under Earth-Mars joint operation
	4	+|**Description**|A photobioreactor as the air revitalization component of the Hab life support system, equipped with a situationally aware and interactive sensor network. The study also assesses the psychological impact, reactor control from Earth and crew interfacing.
	5	+|**Principal Investigator (PI)**|Christiane Heinicke ~| [[christiane.heinicke@zarm.uni-bremen.de>>mailto:christiane.heinicke@zarm.uni-bremen.de]]
	6	+|**Organisation** |ZARM -Center of Applied Space Technology and Microgravity, University of Bremen
	7	+|**Co-Investigators**|Vera Hagemann, Faculty of Business Studies and Economics, University of Bremen ~| [[vhagemann@uni-bremen.de>>mailto:vhagemann@uni-bremen.de]]
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11	11	=== Summary ===
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15	15	[[image:ACT_manifest.png||height="266" width="399"]]
16	16	)))
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18		-Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during spaceexplorationmissions, e.g.to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew.Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
	16	+Astronauts experience psychological challenges during a planetary mission caused by isolation from other human beings. Moreover, astronauts are dependent on the Life Support System (LSS) to withstand the rough, Martian environmental conditions. A proper, human centered LSS, which is controlled and understood easily by the astronaut is essential for a successful Mars mission.
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20		-The main objective of Genes4Mars is a retrospective investigation of changes inrisk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG)analysis can be used to monitor astronaut performanceduring planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiacfunction-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
	18	+Staying Alive deals with the revitalizing component of the LSS in a habitat in form of a photobioreactor (PBR). PBRs have already been researched in the past, however, only a scientific basis. Staying Alive comprises three aspects of the PBR:
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	20	+* Communication and operation
	21	+* The user interface
	22	+* Contribution to the crew’s mental health
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	24	+The aim of Staying Alive is to investigate the interaction between the astronaut and the PBR. Additionally, a highly interactive sensor system will be tested. The sensor network shall be able to communicate with humans to learn from experience and new data, to explain its decisions and thus become a team member rather than a data source.
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	26	+For the mission experiment, a small and simplified PBR will be used in the AMADEE-24 habitat. It uses non-toxic photosynthetic organismsto produce oxygen from ambient air and will be equipped with sensor and a user interface for interaction. During the experiment the crew must perform several tasks once fully autonomously and once jointly with the Mission Support Center (MSC). The tasks to be performed include set-up, maintenance, repair, and science activities. Pre-and post-mission questionnaires as wellas video recording will be used to obtain data.
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26	26	=== Experiment Data ===
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