Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-Pressure
	1	+Amadee-24-Genes4Mars

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1	1	=== Details ===
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3		-|**Acronym**|PRESSURE
4		-|**Description**|Crew stress simulation -emergency situation (technical/medical type) where teams will have to organize and execute a rescue operation during an EVA. The emergency scenario will consist of a combined technical and not serious medical condition.The technical problem will be simulated by time constrained problem-solving tasks.
5		-|**Principal Investigator (PI)**|Gabriel G. de la Torre ~| [[gabriel.delatorre@uca.es>>mailto:gabriel.delatorre@uca.es]]
6		-|**Organisation** |University of Cadiz
	3	+|**Acronym**|Genes4Mars
	4	+|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
	5	+|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
	6	+|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
7	7	|**Co-Investigators**|(((
8		-Celia Avila-Rauch | [[windrosecoaching@outlook.com>>mailto:windrosecoaching@outlook.com]]
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10		-Miguel A. Ramallo | [[miguelangel.ramallo@uca.es>>mailto:miguelangel.ramallo@uca.es]]
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12		-Sara Gonzalez-Tore | [[sara.gtm@uca.es>>mailto:sara.gtm@uca.es]]
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14		-Lucie Rackova | [[lucie.rackova@recetox.muni.cz>>mailto:lucie.rackova@recetox.muni.cz]]
	8	+Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
15	15	)))
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17	17	=== Summary ===
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21	21	[[image:ACT_manifest.png||height="266" width="399"]]
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24		-Astronauts are often exposed to an extreme environment, several health risks, and stressors. They all influence the astronaut’s performance including neurocognitive, mood and behavioral problems. Extra-vehicular activities (EVA) are one of the most dangerous tasks. Therefore, it is important to identify and mitigate the risks and challenges associated with EVAs
	18	+Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during spaceexplorationmissions, e.g.to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew.Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
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26		-The terrestrial ‘Golden Period’ emergency concept is one that will also be applicable to planetary EVA emergencies. Training and practicing this concept are crucial for space mission success. These emergencies may happen as a result technical malfunctions,medical circumstances, environmental danger, etc.
	20	+The main objective of Genes4Mars is a retrospective investigation of changes inrisk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG)analysis can be used to monitor astronaut performanceduring planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiacfunction-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
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28		-This experiment aims to establish emergency simulation scenarios during EVAs where cognitive, emotional, and psychosocial skills will be relevant. The performances of the analog astronauts as well as their teamwork will be analyzed and emergency protocols for EVA emergencies will be tested.
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30		-During simulated EVA emergency scenarios different aspects of response to these emergencies by the crew (psychological, cognitive, problem solving, team dynamics) will be studied. Special focus will lie on emergencies where fast, accurate problem solving, and calculation may be needed to solve some strategic or vital equipment. In order to solve those problems in a timely manner, cognitive processing, task solving, and teamwork will be necessary.
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34	34	=== Experiment Data ===