Changes for page Amadee-24-Genes4Mars

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1		-Amadee-24-IAQHabitat
	1	+Amadee-24-Genes4Mars

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1	1	=== Details ===
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3		-|**Acronym**|IAQHabitat
4		-|**Description**|Habitat indoor air quality measurement.
5		-|**Principal Investigator (PI)**|Jan Gunschera ~| [[jan.gunschera@wki.fraunhofer.de>>mailto:jan.gunschera@wki.fraunhofer.de]]
6		-|**Organisation** |Fraunhofer WKI
	3	+|**Acronym**|Genes4Mars
	4	+|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
	5	+|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
	6	+|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
7	7	|**Co-Investigators**|(((
8		-Sebastian Wientzek | [[sebastian.wientzek@wki.fraunhofer.de>>mailto:sebastian.wientzek@wki.fraunhofer.de]]
	8	+Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
9	9	)))
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11	11	=== Summary ===
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15	15	[[image:ACT_manifest.png||height="266" width="399"]]
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18		-Air quality is an important factor for terrestrial indoor environments, such as buildings, individual or public traffic, and others. In space, this aspect was less important due to relatively short stays of astronauts. However, in the near future, stays of astronauts in space will become longer, especially when considering astronautic missions to and on Mars. Therefore, indoor air quality (IAQ) in extra‐terrestrial environments like spaceships or habitats has attracted notice.
	18	+Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during space exploration missions, e.g. to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew. Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
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20		-Investigations on the indoor air quality (IAQ) of spaceships are rare and were mainly performed on the ISS, mostly using online methods directly in the station. But one must consider that for longer trips and stays an astronaut’s stress level is increased.Therefore, aspects like well‐being will play a major role. Consequently, long‐term investigations on emissions from materials and indoor air quality (IAQ) will be necessary in the future to ensure astronauts’healths.
	20	+The main objective of Genes4Mars is a retrospective investigation of changes in risk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG) analysis can be used to monitor astronaut performance during planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiac function-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
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22		-The aim of IAQHabitat is to estimate the relevance of indoor air quality (IAQ) and the applicability of today’s assessment methods concerning IAQ on long term missions.
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24		-For one week, air samples shall be taken in the habitat to measure the concentrations of volatile organic compounds (VOC), very volatile organic compounds (VVOC), short chained aldehydes and organic acids. Samples that will be taken twice per day on sorbents have to be sent to WKI for further analysis. Whereas other samples in the habitat can be taken and analyzed in-situ using an equipment. Additionally, it is planned to take two measurements in the outdoor air to look for potential influences.
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28	28	=== Experiment Data ===
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