Changes for page Amadee-24-Genes4Mars

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1	1	=== Details ===
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3		-|**Acronym**|ACT
4		-|**Description**|Utilizing Acceptance and Commitment Therapy to improve participants’ psychological flexibility, stress and well-being, performance and error measures
5		-|**Principal Investigator (PI)**|Karoly Schlosser
6		-|**Organisation** |Institute of Management Studies, Goldsmiths University of London
7		-|**Co-Investigators**|n/a
	3	+|**Acronym**|Genes4Mars
	4	+|**Description**|Astronaut performance and health monitoring with automated ECG andinvestigation of the changes in health-risk-associated gene expression patterns in blood and urine samples of astronauts.
	5	+|**Principal Investigator (PI)**|Dr. Arsen Arakelyan ~| [[arsen.arakelyan@rau.am>>mailto:arsen.arakelyan@rau.am]]
	6	+|**Organisation** |Institute of Biomedicine and Pharmacy, Russian-Armenian University; Institute of Molecular Biology NAS RA
	7	+|**Co-Investigators**|(((
	8	+Karen Avetisyan | [[avetisyan2016@gmail.com>>mailto:avetisyan2016@gmail.com]]
	9	+)))
8	8
9	9	=== Summary ===
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13	13	[[image:ACT_manifest.png||height="266" width="399"]]
14	14	)))
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16		-Astronauts are at all times required to provide outstanding performance. They are to remain resilient and to maintain their psychological well-being in order to successfully accomplish their mission in extreme and isolated environments. Future Martian explorers therefore have to be selected and trained to be able to deal with such environments and to be able to maintain an adaptive and resilient mind-set, communicate with others efficiently and pro-actively, process and accept worries and sadness, and to stay persistent with respect to the goals of the mission.
	18	+Long-term space missions are known to be associated with health risks to astronauts because of environmental factors, such as radiation, microgravity, and lasting isolation. These risks could be more aggravating during space exploration missions, e.g. to Mars, especially with limited access to healthcare facilities. It is suspected that space flights and planetary missions could have performance degradation and negative effects on the cardiovascular health of the crew. Therefore, the development of biomarker-based and physiological predictors of health risks for the assessment of physiological conditions is of vital importance.
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18		-In the course of the experiment, all six analog astronauts will be trained in Acceptance and Commitment Therapy (ACT). In a wide range of studies, ACT has proven to increase people’s psychological flexibility; this is, their ability to pursue their important goals, even when they experience thoughts, feelings, fears, and emotions that may get in the way of their moving towards those goals. The ACT training will focus on providing key, practical skills that the participants can use in carrying out their daily activities, as well as in interacting with their colleagues. This study aims to assesses the ability of ACT to improve participants’ psychological flexibility, stress and well-being, performance and error measures, narrative contents and communication patterns, cognitive and physiological outcomes.
	20	+The main objective of Genes4Mars is a retrospective investigation of changes in risk-associated gene expression patterns in blood and urine samples from the Analog Astronauts. It will also investigate how well automated electrocardiogram (ECG) analysis can be used to monitor astronaut performance during planetary missions, and whether ECG can be used as a surrogate marker for dynamic changes in cardiac function-related genes. The members of the flight crew could be considered as a case group and the back-up flight crew members could function as a control group. The samples will be collected from each participant at multiple time points pre-, during and past-mission and will be analysed after the mission is completed. RNA will be extracted from the samples immediately upon their transfer to the lab and analysed for up-or downregulated genes. Additionally, 12-lead and single-lead ECGs of each participant should be taken one week prior to the start of the mission and each day before and after field assignments outside the habitat. After the end of the mission, the data will be analysed using deep learning methods and pre-trained models to detect heart pathologies. Correlation and regression analysis will be used to find the association between gene expression and physiological parameters.
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20		-The study will use a pre - post-test design. The pre-test will be completed by the participants before the ACT training, a post-test after completing the training. Further, a follow-up measure will be taken from participants at the end of their mission. Additional qualitative data will be collected from the analog astronauts in form of a diary.
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22	22	=== Experiment Data ===
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24	24	(% style="height:10px; width:1000px" %)
25	25	|=(% style="width: 127px;" %)Date|=(% style="width: 871px;" %)Files
26		-|(% style="width:127px" %)[[2021-10-04>>https://mission.oewf.org/archive_downloads/amadee20/ACT/2021-10-04]]|(% style="width:871px" %)files
	28	+|(% style="width:127px" %)[[2021-10-04>>https://mission.oewf.org/archive_downloads/amadee20/ACT/2021-10-04]]|(% style="width:871px" %)types of files for each experiment day, size of the cells: width 1000px, height 10px
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